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Hypertension and Pre diabetesInsulin Resistance and obesity-linked Pre-Diabetes can be an increased risk factor for hypertension, or high blood pressure - one of the most important risk factors for Cardiovascular Disease, which can lead to a heart attack or stroke.

If left untreated, hypertension can also lead to a wide variety of other life-threatening conditions, such as kidney damage and congestive heart failure.

Hypertension is a serious health problem for several reasons: it is very common with wide-spread consequences and can remain asymptomatic (undiagnosed) until relatively late in its course. Numerous studies have proven that Insulin Resistance and resulting hyperinsulinemia (elevated insulin in the blood) cause increases in blood pressure. This is because elevated levels of insulin can cause atherosclerosis, which directly affects the diameter of the inside of the blood vessels by the build-up of plaque on the artery walls.

Blood pressure is determined by cardiac output - how much blood the heart is pumping per beat, total peripheral resistance and how easily the blood is pumped to the farthest points of the body. Blood pressure itself is affected by various factors, such as genetics, lifestyle and environment. The higher the blood pressure, the greater the chances of sustaining kidney damage and suffering a heart attack or stroke.

Think of your vascular system as a complex, interlocking web of hoses, similar to the garden variety. The smaller the size of the hose, the more pressure on all of the other hoses as less blood flows through per minute. The heart must pump harder to get blood to distant sites while facing the decreased diameter of vessels. This increases the pressure on the entire cardiovascular system, causing elevated blood pressure.

Atherosclerosis occurs when deposits of fatty substances like cholesterol, cellular waste products and other material build up in the inner lining of an artery. This build-up is commonly called plaque and most scientists agree it begins with damage to the innermost layer of the artery wall. Causes of this damage come from elevated levels of LDL "bad" cholesterol and fat-carrying blood lipids called triglycerides in the blood, as well as high blood pressure, tobacco smoke and Pre-Diabetes.

Insulin Resistance Underlies Pre-Diabetes

Chronic elevations of glucose and insulin levels are classic symptoms of Insulin Resistance, which is an underlying cause of Pre-Diabetes. One of the primary risk factors for atherosclerosis is an elevated level of triglycerides. The biggest risk factor, in turn, for increasing the production of triglycerides is the rate of your insulin secretion.

Hypertension and PREDAs excess insulin caused by Insulin Resistance comes in contact with the interior wall of the arteries, it is caustic to the tissue, causing the initial injury that can lead to plaque. As plaque builds up on the interior wall of the arteries, the circumference of the arteries decreases, thus increasing the pressure of the blood rushing through the entire vascular system.

This complex interaction becomes a serious health concern because, as high blood pressure rises, the chances of life-threatening medical conditions also increase.

Another factor in Pre-Diabetes and heart disease may be the role of inflammation, which is part of the body's immune system.

Inflammation triggers a defense response to harmful stimuli or injury by sending specialised blood cells to damaged areas where they attack "invaders" like the renegade molecules called "free radicals" and clean up dead and dying cells.

In the case of inflammation and Pre-and Type 2 Diabetes, the "invader" is thought to be excess levels of insulin, which can be caused by the imbalance of blood glucose and insulin called Insulin Resistance.

Inflammation can take an external form like the reddened, tender skin which draws attention to a splinter in your finger. Or it can be an unseen, internal process in response to something harmful like high blood pressure.

To combat internal harm, inflammation produces C-reactive protein (CRP), which, unfortunately, can damage the arteries by helping to form plaque while attempting to tackle a long-term condition like high blood pressure - often an accompanying symptom of Pre-Diabetes.

Plaque is a substance that attaches itself to artery walls, damaging those walls and seriously impairing blood flow, which can leading to a heart attack or stroke. A blood test measures CRP levels and the higher that level is, the more at risk you are from cardiovascular disease. There's contradictory evidence about whether CRP levels and Insulin Resistance are closely linked.

Research about inflammation is often cutting edge material that still needs ample verification. But scientists are gathering data that inflammation precedes and may predict reversible Pre-Diabetes, which, if left unchecked, can lead to the onset of Type 2 Diabetes.

Previous research had already linked inflammation to heart disease and obesity, which are both common in people with Pre-Diabetes. To learn more, click on Inflammation, Insulin Resistance and Pre-Diabetes.

Hypertension makes your heart work harder than normal and, as a result, both the heart and arteries are more prone to injury. High blood pressure increases the risk of heart attacks, stroke, kidney failure, eye damage and congestive heart failure. If you have hypertension, are obese, smoke or have high blood cholesterol levels or Pre-Diabetes, your risk of heart attack or stroke goes up dramatically.

Untreated high blood pressure forces your heart to work harder to pump enough blood and oxygen to your body's organs and tissues. It also damages arteries and arterioles, the very small arteries that connect larger arteries to tiny capillaries. Arterial damage is a serious health issue because hardened or narrowed arteries may not be able to supply enough blood to your body's organs, thus reducing their ability to function properly. In addition, plaque may dislodge from the sides of the artery wall, forming a blockage in another part of your body and causing a heart attack or stroke.

Although there are pharmaceuticals that can help lower blood pressure, the Insulite Pre-Diabetes System is the only complete multi-layered program that includes nutraceuticals (disease specific vitamins, herbs and minerals), nutrition and exercise plans and a client support network of doctors to help reverse Insulin Resistance and Pre-Diabetes.

Click here to read about a scientific breakthrough called the Insulite Pre-Diabetes System. This unique system features formulations like Pre-SensitX, which includes Oregon Grape Root, a nutraceutical that raises insulin sensitivity and lowers blood glucose levels.

You may be interested in some related information on Pre-Diabetes and the Insulite Pre-Diabetes System:

Click here to read about Pre-Diabetes and Heart Health


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"I have been on the Insulite Pre-Diabetes System for one year. Within that year I have lost 76 pounds and my glucose level has improved. I followed the plan provided and have also become physically fit. I am able to exercise 2+ hours a day and hike difficult treks at the parks without fatigue. I feel better and healthier than I have in a very long time. I wish to tell others what a wonderful system this is. I have ordered another year of the Pre-Diabetes System and expect that the improvements will keep coming."
  Austin, TX
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"Nearly 21 million Americans are believed to be diabetic, according to the Centers for Disease Control, and 41 million more are Pre-Diabetic; their blood sugar is high, and could reach the diabetic level if they do not alter their living habits."
Diabetes and Its Awful Toll Quietly Emerge as a Crisis"
New York Times
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It's reassuring to know that there is help for me and other people with Pre-Diabetes."
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Diabetes or Pre-Diabetes Now Strikes One in Four Americans:
The number of Americans with diabetes has grown to about 24 million people, or roughly 8 percent of the U.S. population. Read more...
"I have been on the Insulite Pre-Diabetes System for 6 months now. I have lost 52.5 lbs and am walking 5 miles a day, 6 days a week. I feel great! I still have a hard time believing that this has worked so well and so easily. I have tried to lose weight for years and had even come to the point of gaining weight while fasting.

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About Pre-Diabetes

Pre-diabetes and Cardiovascular Disease

Diabetes Myths

Related Conditions to Prediabetes

Pre-diabetes and Inflammation

Glycemic Index

Insulin Resistance

Vitamins and Minerals

Pre-Diabetes System

About Insulite Laboratories

"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
Pre-diabetes Newsletter Archive
"I wanted to let you know how much I appreciate your caring advice and guiding me towards taking control of my health. It's hard to express in words how long I have been trying to find the answers you have so easily provided for me.

I am so excited about the positive changes in my health and I can't wait to see where I am six months from now, yet alone the year. Thank you again!"
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"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
Article by Dr. Sheri Colberg, Phd, FACSM
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  Perth, Australia

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