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Pre-Diabetes and High CholesterolIndividuals suffering from reversible, Insulin Resistance-linked Pre-Diabetes are at severely increased risk of developing Type 2 Diabetes, a condition which may lead to Cardiovascular Disease.

The latter condition is one of the biggest killers of men and women in the United States, according to the American Heart Association.

Victims of Pre-Diabetes often suffer from elevated cholesterol levels, hypertension (high blood pressure) and Insulin Resistance-linked obesity - all factors which sharply increase the risk of heart disease.

Coronary heart disease (CHD) is a broad term that describes any disorder that can impact the functioning of the heart muscle itself or the cardiovascular system. Conditions that contribute to heart disease include hypertension, arteriosclerosis (the build-up of calcium deposits on the artery wall) and atherosclerosis (the build-up of fatty deposits on the artery wall).

The causes of heart disease include: elevated LDL "bad" cholesterol, low HDL "good" cholesterol and high levels of triglycerides (substances that store fat for energy and are carried throughout the blood stream to the tissues). Other causes are obesity, Type 2 Diabetes, stress, cigarette smoking and lack of physical activity.

Another factor in Pre-Diabetes and Cardiovascular Disease may be the role of inflammation, which is part of the body's immune system. Inflammation triggers a defense response to harmful stimuli or injury by sending specialized blood cells to damaged areas where they attack "invaders" like the renegade molecules called "free radicals" and clean up dead and dying cells.

In the case of inflammation and Pre-Diabetes, the "invader" is thought to be excess levels of insulin, which can be caused by the imbalance of blood glucose and insulin called Insulin Resistance.

Inflammation can take an external form like the reddened, tender skin which draws attention to a splinter in your finger. Or it can be an unseen, internal process in response to something harmful like high blood pressure.

To combat internal harm, inflammation produces C-reactive protein (CRP), which, unfortunately, can damage the arteries by helping to form plaque while attempting to tackle a long-term disorder like high LDL cholesterol levels - often an accompanying symptom of Pre-Diabetes.

Plaque is a substance that attaches itself to artery walls, damaging those walls and seriously impairing blood flow, which can leading to a heart attack or stroke. A blood test measures CRP levels and the higher that level is, the more at risk you are from Cardiovascular Disease. There's contradictory evidence about whether CRP levels and Insulin Resistance are closely linked.

Research about inflammation is often cutting edge material that still needs ample verification. But scientists are gathering data that inflammation precedes and may predict reversible Pre-Diabetes, which, if left unchecked, can lead to the onset of Type 2 Diabetes.

This latter condition can only be managed for the rest of a Diabetic's life in the vast majority of cases and may require daily injections of insulin. Type 2 Diabetes, itself, is a severely increased risk factor for blindness, heart and kidney disease and the need for amputation.

Previous research had already linked inflammation to heart disease and obesity, which are both common in people with Pre-Diabetes. To learn more, click on Inflammation, Insulin Resistance and Pre-Diabetes.

Symptoms of Insulin Resistance and Pre-Diabetes

Pre-Diabetes and High CholesterolChronic high levels of glucose and insulin are classic symptoms of Insulin Resistance and Pre-Diabetes, which can lead to heart disease.

One of the primary risk factors for atherosclerosis, or hardening of the arteries, is an elevated level of blood lipids called triglycerides. The biggest risk factor for increasing the production of triglycerides is the rate of insulin secretion, which can be severely affected by Insulin Resistance.

Insulin is produced in the pancreas and released into the circulatory system where it is the key to the absorption of glucose by your cells for energy. If the cells resist insulin, then both insulin and glucose build up in the blood stream. Excess insulin leads to weight gain and hypertension - both precursors to Cardiovascular Disease and Pre-Diabetes. As excess insulin comes in contact with the interior wall of the arteries, it damages the tissue.

Additionally, LDL cholesterol particles seen in people who suffer from Insulin Resistance are smaller and more dense than those of people without this condition. This factor has been directly linked to an increased risk of Cardiovascular Disease, heart attacks and stroke, although the exact cause of the relationship is unclear.

Increased LDL cholesterol is one of the underlying symptoms that can trigger a blood test diagnosis of Pre-Diabetes, which, if neglected, may lead to Type 2 Diabetes. This latter condition is lifelong and may require daily insulin.

Obesity, elevated insulin, high blood lipids, poor diet and physical inactivity are known to have an effect on the development of high levels of cholesterol.

Scientists and health care professionals have been warning in recent years of the dangers of high cholesterol. In general, the lower a person's LDL, and the higher their HDL, the lower the risk of Cardiovascular Disease.

Lifestyle Changes are Vital

Pre-Diabetes and High CholesterolThe National Cholesterol Education Program (NCEP) advises that addressing high levels of cholesterol is critical. "But the idea that you can use cholesterol-lowering drugs without lifestyle changes is incorrect," said Scott Grundy, M.D., Ph.D. and the American Heart Association's representative to the NCEP.

"Lifestyle changes have enormous benefits beyond lowering LDL cholesterol, such as raising levels of good cholesterol, lowering triglycerides, improving Pre-Diabetes and reducing inflammation of the arteries," Grundy concluded.

Recommendations for reducing heart disease risk are the same as those for combating Insulin Resistance, namely losing weight to decrease insulin levels by avoiding carbohydrates, balancing cholesterol and lowering blood pressure.

Reversing Pre-Diabetes can help reduce the underlying conditions that lead to heart disease as well as preventing Type 2 Diabetes.

The risks of developing Pre-Diabetes and heart disease can be reversed or reduced through careful food choices, exercise and weight loss in obese individuals. But a multi-faceted approach is clearly necessary to address all the symptoms of these conditions.

What's needed to address the issues presented by these disorders is a complete system, including nutraceuticals (vitamins, herbs and minerals that are disease specific), a realistic exercise program combined with nutritional guidance and a support network that will help you change unhealthy lifestyle choices.

Click here to read about the Insulite Pre-Diabetes System, a unique, scientifically-designed program to reverse Pre-Diabetes before it develops into Type 2 Diabetes, creating a severely increased risk for cardiovascular disease. Among the system's formulations is Pre-SensitX, which contains vanadium sulfate, a compound that lowers cholesterol and increases insulin sensitivity.

You may be interested in some Frequently Asked Questions (FAQs) about Pre-Diabetes and the Insulite Pre-Diabetes System:

Click here to read about Pre-Diabetes and Heart Disease


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"I have been on the Insulite Pre-Diabetes System for one year. Within that year I have lost 76 pounds and my glucose level has improved. I followed the plan provided and have also become physically fit. I am able to exercise 2+ hours a day and hike difficult treks at the parks without fatigue. I feel better and healthier than I have in a very long time. I wish to tell others what a wonderful system this is. I have ordered another year of the Pre-Diabetes System and expect that the improvements will keep coming."
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"Nearly 21 million Americans are believed to be diabetic, according to the Centers for Disease Control, and 41 million more are Pre-Diabetic; their blood sugar is high, and could reach the diabetic level if they do not alter their living habits."
Diabetes and Its Awful Toll Quietly Emerge as a Crisis"
New York Times
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Diabetes or Pre-Diabetes Now Strikes One in Four Americans:
The number of Americans with diabetes has grown to about 24 million people, or roughly 8 percent of the U.S. population. Read more...
"I have been on the Insulite Pre-Diabetes System for 6 months now. I have lost 52.5 lbs and am walking 5 miles a day, 6 days a week. I feel great! I still have a hard time believing that this has worked so well and so easily. I have tried to lose weight for years and had even come to the point of gaining weight while fasting.

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About Pre-Diabetes

Pre-diabetes and Cardiovascular Disease

Diabetes Myths

Related Conditions to Prediabetes

Pre-diabetes and Inflammation

Glycemic Index

Insulin Resistance

Vitamins and Minerals

Pre-Diabetes System

About Insulite Laboratories

"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
Pre-diabetes Newsletter Archive
"I wanted to let you know how much I appreciate your caring advice and guiding me towards taking control of my health. It's hard to express in words how long I have been trying to find the answers you have so easily provided for me.

I am so excited about the positive changes in my health and I can't wait to see where I am six months from now, yet alone the year. Thank you again!"
  Stuarts Draft, VA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
Article by Dr. Sheri Colberg, Phd, FACSM
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  Perth, Australia

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