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PRE-DIABETES AND HEART DISEASE


Insulin Resistance-linked obesity can be a root cause of Pre-Diabetes, which, if neglected, may lead to Type 2 Diabetes, a severely increased risk factor for heart disease.

When the body becomes Insulin Resistant, it begins a cycle which leads to the release of more and more insulin to compensate for an increase in blood sugar levels. This elevation in insulin is called hyperinsulinemia, as pancreatic insulin secretion rises to maintain normal levels of glucose in the blood. An excess of insulin in the blood stream and an increased risk of high cholesterol levels are major risk factors for the onset of Pre-Diabetes and damage to the cardiovascular system.

Hyperinsulinemia can stimulate lipid storage (fat storage throughout the body) and alter lipoprotein levels thereby increasing cholesterol. The resulting excess of insulin also encourages the liver to produce more of the blood lipids called triglycerides, which store fat for energy and pass through the blood stream to the tissues.

This blood fat disorder is called Dyslipidemia, which fosters plaque build-up in artery walls. Dyslipidemia is diagnosed when LDL (low-density lipoprotein or "bad" cholesterol) is high, HDL (high density lipoprotein or "good" cholesterol) is low, triglycerides levels are high or there a combination of all these factors, which are associated with an increased risk for heart disease.

Additionally, LDL cholesterol particles seen in people who suffer from Insulin Resistance and Pre-Diabetes are smaller and more dense than those of people without this condition. This factor has been directly linked to an increased risk of Cardiovascular Disease, heart attacks and stroke, although the exact cause of the relationship is unclear.

Increased LDL cholesterol is one of the underlying symptoms that can trigger a blood test diagnosis of reversible Pre-Diabetes, which, if neglected, can lead Type 2 Diabetes. This latter condition can only be managed – not reversed – and may require daily insulin. Obesity, elevated insulin, high blood lipids, poor diet and physical inactivity are known to have an effect on the development of high levels of cholesterol.

Another factor in Pre-Diabetes and heart disease is the role of inflammation, which is part of the body's immune system. Inflammation triggers a defense response to harmful stimuli or injury by sending specialized blood cells to damaged areas where they attack "invaders" like the renegade molecules called "free radicals" and clean up dead and dying cells.

In the case of inflammation and Pre-Diabetes, the "invader" is thought to be excess levels of insulin, which can be caused by the imbalance of blood glucose and insulin called Insulin Resistance.

Inflammation can take an external form like the reddened, tender skin which draws attention to a splinter in your finger. Or it can be an unseen, internal process in response to something harmful like high blood pressure.

To combat internal harm, inflammation produces C-reactive protein (CRP), which, unfortunately, can damage the arteries by helping to form plaque while attempting to tackle a long-term condition like high blood pressure or high LDL cholesterol levels - often accompanying symptoms of Pre-Diabetes.

Plaque is a substance that attaches itself to artery walls, damaging those walls and seriously impairing blood flow, which can lead to a heart attack or stroke. A blood test measures CRP levels and the higher that level is, the more at risk you are from cardiovascular disease. There's contradictory evidence about whether CRP levels and Insulin Resistance are closely linked.

Research about inflammation is often cutting edge material that still needs ample verification. But scientists are gathering data that inflammation precedes and may predict reversible Pre-Diabetes, which, if left unchecked, can lead to the onset of Type 2 Diabetes.

Previous research had already linked inflammation to heart disease and obesity, which are both common in people with Pre-Diabetes. To learn more, click on Inflammation, Insulin Resistance and Pre-Diabetes.

Although there are approved drugs that can help lower cholesterol levels, there are currently no drugs that will completely reverse the symptoms of Insulin Resistance and Pre-Diabetes. The same is true of related conditions like Metabolic Syndrome (Syndrome X) and the hormonal disorder called Polycystic Ovarian Syndrome (PCOS), a leading cause of female infertility as well as menstrual irregularity, skin conditions and excess body and facial hair. All Insulin Resistance-linked disorders are increased risk factors for Cardiovascular Disease leading to a heart attack or stroke.

You must rely on a multi-faceted approach to improving these conditions. A complete system is recommended, including nutraceuticals (vitamins, herbs and minerals that are disease-specific), a realistic exercise program combined with nutritional guidance and a support system that will help you adopt a healthier lifestyle choices.

Click here to read about the new scientific breakthrough called the Insulite Pre-Diabetes System, which can help reverse Pre-Diabetes, and prevent the onset of Type 2 Diabetes and its attendant risk of heart disease.

The system features a series of scientifically-designed formulations like RejuvenX, which includes CoQ10, a powerful anti-oxidant that lowers glucose and insulin levels, and Vitamin C to reduce damage to arteries.

You may be interested in some related information on Pre-Diabetes and the Insulite Pre-Diabetes System:

Click here to read about Pre-Diabetes and Hypertension (High Blood Pressure)

 

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"I have been on the Insulite Pre-Diabetes System for 6 months now. I have lost 52.5 lbs and am walking 5 miles a day, 6 days a week. I feel great! I still have a hard time believing that this has worked so well and so easily. I have tried to lose weight for years and had even come to the point of gaining weight while fasting.

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Sheryl Ward
  Hernando, MS
Pre-Diabetes Articles
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  Santa Ana, CA
"Nearly 21 million Americans are believed to be diabetic, according to the Centers for Disease Control, and 41 million more are Pre-Diabetic; their blood sugar is high, and could reach the diabetic level if they do not alter their living habits."
Diabetes and Its Awful Toll Quietly Emerge as a Crisis"
New York Times

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Pre-Diabetes and IR in the News
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CBS News
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PR
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  England
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"Simply losing 5-7% of your body fat (typically 10-15 pounds) and increasing your physical activity by taking a brisk walk 4-5 times a week can reduce your risk of developing Type II Diabetes by almost 60%."
Diabetes Prevention Program study 2001, study funded by the National Institute of Child Health and Human Development, et al.
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"I wanted to let you know how much I appreciate your caring advice and guiding me towards taking control of my health. It's hard to express in words how long I have been trying to find the answers you have so easily provided for me.

I am so excited about the positive changes in my health and I can't wait to see where I am six months from now, yet alone the year. Thank you again!"
MS
  Stuarts Draft, VA
"...approximately 90% of overweight Hispanic children with a family history for type 2 diabetes have at least one feature of the metabolic syndrome and 30% possess the metabolic syndrome.

Our results support the view that improving insulin resistance may be crucial in the prevention of both type 2 diabetes and premature cardiovascular disease in this at-risk subpopulation of Hispanic youth."
Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI.,J Clin Endocrinol Metab. 2004 Jan;89(1):108-13.
Article by Dr. Sheri Colberg, Phd, FACSM
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